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Rischio cardiovascolare nel paziente con Lupus eritematoso

High prevalence of subclinical cardiovascular abnormalities in patients with systemic lupus erythematosus in spite of a very low clinical damage index.

Palmieri V , Migliaresi P , Orefice M , Lupo T , Di Minno MN , Valentini G , Celentano A .


Unit of Cardiology, Ospedale dei Pellegrini, ASL Napoli 1, Naples, Italy. vpalmier@med.cornell.edu


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BACKGROUND AND AIM: To evaluate the prevalence of subclinical cardiovascular (CV) abnormalities in systemic lupus erythematosus (SLE) stratified according to SLE-related organ damage using the Systemic Lupus International Collaborating Clinics (SLICC) damage index. METHODS AND RESULTS: We selected SLE patients without clinically overt CV events (n=45, 56% with SLICC=0, 44% with SLICC=1-4). CV evaluation was performed using cardiac and vascular echo-Doppler techniques. Post-ischemic flow-mediated dilation (FMD) over nitroglycerine-mediated dilation (NMD) of the brachial artery